Proton Pump Inhibitors (PPIs)
Clopidogrel requires activation by the CYP2C19 enzyme. Loss-of-function alleles can reduce active metabolite exposure 5 to 10-fold.
Statin Myopathy Risk Panel
Clopidogrel requires activation by the CYP2C19 enzyme. Loss-of-function alleles can reduce active metabolite exposure 5 to 10-fold.
Malignant Hyperthermia (MH) Screening
Clinical MH crises occur in roughly 1 in 10,000 pediatric and 1 in 50,000 adult anesthetics.
Irinotecan Toxicity Risk Panel
Irinotecan's active metabolite (SN-38) is inactivated by UGT1A1. Reduced-function alleles (*28, *6) slow this process, increasing SN-38 exposure and the risk of severe side effects.
Clopidogrel Response Panel
Clopidogrel requires activation by the CYP2C19 enzyme. Loss-of-function alleles can reduce active metabolite exposure 5 to 10-fold.
Allopurinol Hypersensitivity Screen
HLA-B*58:01 Pharmacogenomic Panel Fast Facts — Why Genotyping Before the First Dose Matters